Often, opioids are discussed in the context of addiction and abuse, but even under physician supervision, patients using these drugs can experience a wide range of side effects including withdrawal syndrome, dry mouth, constipation, and confusion. Other drugs used to treat nervous system disorders appeared on our list as well, with numerous opioids also making an appearance. Citalopram, a selective serotonin reuptake inhibitor (SSRI) prescribed to treat depression, had 771 side effects, followed by aripiprazole, an antipsychotic used to treat schizophrenia and other psychiatric conditions. Medications that treat the nervous system, including common antidepressants, have the highest number of side effects. Which Drugs Have the Most Documented Side Effects? Taking prescription drugs should be a positive experience that improves people's overall sense of health, so read on to learn how common medications compare to one another when it comes to their side effects. Although drugs go through several rounds of trials, extreme adverse effects can still occur once medications have been released into the market for public use, resulting in injury, illness, and in some cases, death. Food and Drug Administration as a part of the drug approval process. Many of these side effects are found during clinical trials, which are required by the U.S. We analyzed the SIDER Side Effect Resource, a compilation of globally recognized medications and their side effects, to determine which prescription and over-the-counter drugs had the highest number of and most severe side effects. But what happens when the medicines we rely on cause side effects as severe as the diseases or conditions they're supposed to treat? One study shows that more than half of all Americans take at least one prescription drug. To say medicine has had a profound effect on many people's quality of life would be an understatement.
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